In a box Jellyfish sting, thousands of microscopic hypodermic needle-like nematocyst tubules fire off at “bullet speed” to inject a potent venom cocktail. Work in our laboratory over the past 20 years has focused on solving the mysteries of these formidable stingers including answering the questions of “What are box jellies?”, “What is in the venom?”, “Why do box jelly stings cause so much pain and sometimes death?”, and “What is the best way to treat a sting?”. These topics will all be discussed together with video clips of box jelly sting animations, box jelly eyes and scuba videos of collecting box jellies at night off shore of Oahu.